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The Daily Biotech Pulse: Bristol-Myers Squibb's Skin Cancer Readout, Cellect Strikes Reverse Merger Deal, Lava Therapeutics Makes Nasdaq Debut

Here's a roundup of top developments in the biotech space over the last 24 hours: Scaling The Peaks (Biotech Stocks Hitting 52-week Highs March 24) F-star Therapeutics, Inc. (NASDAQ: FSTX) IDEAYA Biosciences, Inc. (NASDAQ: IDYA) Orphazyme A/S (NASDAQ: ORPH) Ortho Clinical Diagnostics Holdings plc (NASDAQ: OCDX) Down In The Dumps (Biotech Stocks Hitting 52-week Lows March 24) Adagene Inc. (NASDAQ: ADAG) Biophytis SA (NASDAQ: BPTS) Concert Pharmaceuticals, Inc. (NASDAQ: CNCE) Connect Biopharma Holdings Limited (NASDAQ: CNTB) (went public Friday) Decibel Therapeutics, Inc. (NASDAQ: DBTX) Dyne Therapeutics, Inc. (NASDAQ: DYN) Epizyme, Inc. (NASDAQ: EPZM) Evaxion Biotech A/S (NASDAQ: EVAX) Finch Therapeutics Group, Inc. (NASDAQ: FNCH) (went public Friday) Forma Therapeutics Holdings, Inc. (NASDAQ: FMTX) Galapagos NV (NASDAQ: GLPG) Galecto, Inc. (NASDAQ: GLTO) Gracell Biotechnologies Inc. (NASDAQ: GRCL) Ibere Pharmaceuticals (NYSE: IBER-UN) Inhibikase Therapeutics, Inc. (NASDAQ: IKT) Karyopharm Therapeutics Inc. (NASDAQ: KPTI) MorphoSys AG (NASDAQ: MOR) Metacrine, Inc. (NASDAQ: MTCR) Odonate Therapeutics, Inc. (NASDAQ: ODT) Olema Pharmaceuticals, Inc. (NASDAQ: OLMA) Reviva Pharmaceuticals Holdings, Inc. (NASDAQ: RVPH) Sarepta Therapeutics, Inc. (NASDAQ: SRPT) Sigilon Therapeutics, Inc. (NASDAQ: SGTX) Talis Biomedical Corporation (NASDAQ: TLIS) uniQure N.V. (NASDAQ: QURE) Universe Pharmaceuticals INC (NASDAQ: UPC) Vallon Pharmaceuticals, Inc. (NASDAQ: VLON) Voyager Therapeutics, Inc. (NASDAQ: VYGR) Stocks In Focus Neurocrine to Join S&P MidCap 400 Index Standard & Poor's announced that Neurocrine Biosciences, Inc. (NASDAQ: NBIX) will replace O-I Glass Inc. (NYSE: OI) in the S&P MidCap 400 effective March 30. The stock was up 8.98% premarket at $95.43. Cellect Biotech to Merge With Specialty Pharma Company Quoin Cellect Biotechnology Ltd. (NASDAQ: APOP) announced a merger agreement with privately held specialty pharma company Quoin Pharmaceuticals Inc. The agreement provides for Cellect shareholders owning 25% of the combined company compared to 75% by Quoin shareholders. Completion of the merger is subject to approval of shareholders of both companies and certain other conditions. The closing of the transaction is expected by the end of the second quarter of 2021. Following the completion of the merger, Cellect will be renamed Quoin Pharmaceuticals and will begin trading on NASDAQ under the symbol QNRX. The stock was up 45.85% premarket at $5.09. Midatech Announces Term Agreement To Co-Develop MTX110 Midatech Pharma plc (NASDAQ: MTP) said the heads of terms of the agreement for codeveloping MTX110 has been agreed, and if the deal progresses to definitive agreements, the company said it expects to receive a modest upfront payment on execution, success-based development and sales milestones and royalties. The company also released headline unaudited results, showing lower revenues and a wider loss for fiscal year 2020. The stock was up 3.41% to $2.12 in premarket trading Thursday. Vertex Announces Australian Regulatory Nod For Triple Combo Cystic Fibrosis Therapy Vertex Pharmaceuticals Incorporated (NASDAQ: VRTX) said the Australian Therapeutic Goods Administration has approved the use of Trikafta for people with cystic fibrosis, ages 12 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator gene, the most common CF-causing mutation worldwide. Related Link: FDA Decisions For Pfizer, Eli Lilly And Bluebird Bio, Bristol-Meyers Squibb, Plus New Data And Earnings Bristol-Myers Squibb Opdivo-Antibody Combo Therapy Aces Phase 2/3 Skin Cancer Study Bristol-Myers Squibb (NYSE: BMY) announced positive primary results from the Phase 2/3 trial evaluating the fixed-dose combination of relatlimab, an anti-LAG-3 antibody, and Opdivo versus Opdivo alone in patients with previously untreated metastatic or unresectable melanoma. The company said the trial met its primary endpoint of progression-free survival. Follow-up for overall survival, a secondary endpoint, is ongoing. Additionally, the fixed-dose combination was well-tolerated and there were no new safety signals reported in either the relatlimab and Opdivo combination arm or the Opdivo arm. G1's Recently Approved Cosela Included In 2 Updated Cancer Treatment Guidelines G1 Therapeutics, Inc. (NASDAQ: GTHX) said its Cosela has been added to two updated National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: the Treatment Guidelines for Small Cell Lung Cancer and the Supportive Care Guidelines for Hematopoietic Growth Factors. View more earnings on IBB It recently won the FDA nod for mitigating the effects of chemotherapy in lung cancer patients. The stock was up 1.76% at $20.80 in premarket trading Thursday. Synlogic Says Hyperoxaluria Treatment Achieves Proof of Mechanism In Phase 1 Study Synlogic, Inc. (NASDAQ: SYBX) announced that SYNB8802 has achieved proof of mechanism in a dietary hyperoxaluria Phase 1 Part A study in which healthy volunteers on a high oxalate and low calcium diet were treated with multiple ascending doses of SYNB8802. In the study's efficacy analysis, the percent change from baseline urinary oxalate levels were negative 28.6% compared to placebo, at the 3e11 live cell dose. This dose was well tolerated and will be used in Part B of the study, the company said. The stock was down 6.96% premarket at $3.61. Radius, Sio-Gene Gain On Insider Transactions Radius Health, Inc. (NASDAQ: RDUS) said in a filing its chief business officer Chhaya Shah exercised options to buy shares. Sio Gene Therapies, Inc. (NASDAQ: SIOX) revealed in a filing its CEO Pawan Cheruvu bought 100,000 shares in the company at $2.4814. In after-hours trading, Radius stock was up 19.49% to $27.50, while Sio Gene gained 8.97% to $2.55. Earnings TELA Bio, Inc.'s (NASDAQ: TELA) fourth-quarter revenue climbed 17% year-over-year to $5.7 million in 2020, and the loss per share narrowed from $1.22 to 54 cents. The stock climbed 14.29% to $16 in after-hours trading. Offerings Evofem Biosciences, Inc. (NASDAQ: EVFM) priced its underwritten public offering of 17.143 million shares of its common stock at a price to $1.75 per share. The gross proceeds from the offering to Evofem are expected to be approximately $30 million. The offering is expected to close on or about March 29. All of the shares of common stock in the offering are to be sold by Evofem. In after-hours trading, the stock fell 10.73% to $2.08. On The Radar Adcom Meeting The FDA's Arthritis Advisory Committee, along with the Drug Safety and Risk Management Advisory Committee will likely announce its recommendation on Pfizer Inc.'s (NYSE: PFE) biologic license application for tanezumab subcutaneous injection for the proposed indication of relief of signs and symptoms of moderate to severe osteoarthritis in adult patients for whom use of other analgesics is ineffective or not appropriate. Tanezumab is being jointly developed by Pfizer and Eli Lilly and Company (NYSE: LLY). Earnings Vascular Biogenics Ltd. (NASDAQ: VBLT) (before the market open) Genetron Holdings Limited (NASDAQ: GTH) (before the market open) Synlogic (before the market open) NovaBay Pharmaceuticals, Inc. (NYSE: NBY) (after the close) Neoleukin Therapeutics, Inc. (NASDAQ: NLTX) (after the close) OpGen, Inc. (NASDAQ: OPGN) (after the close) Eyenovia, Inc. (NASDAQ: EYEN) (after the close) HTG Molecular Diagnostics, Inc. (NASDAQ: HTGM) (after the close) CymaBay Therapeutics, Inc. (NASDAQ: CBAY) (after the close) BIOLASE, Inc. (NASDAQ: BIOL) (after the close) ADMA Biologics, Inc. (NASDAQ: ADMA) (after the close) Athersys, Inc. (NASDAQ: ATHX) (after the close) Processa Pharmaceuticals, Inc. (NASDAQ: PCSA) Panbela Therapeutics Inc. (NASDAQ: PBLA) IPOs Dutch biotechnology Lava Therapeutics B.V., which is developing bispecific antibodies engineered to selectively induce gamma-delta T cell-mediated immunity against tumor cells, priced its 6.7-million share initial public offering at $15, the midpoint of the estimated price range of $14-$16. The company's shares will begin trading on the Nasdaq under the ticker symbol LVTX. Related Link: Attention Biotech Investors: Mark Your Calendar For March PDUFA Dates See more from BenzingaClick here for options trades from BenzingaThe Daily Biotech Pulse: Dynavax-Clover Start Phase 2/3 Vaccine Study. BrainStorm Reports Positive MS Readout, NeoGenomics Goes ShoppingThe Daily Biotech Pulse: FDA Approvals For Merck, Pacira And Zealand, Roche-Regeneron Ace Late-Stage COVID-19 Study, AlloVir Appoints Gilead Virology Chief As CEO© 2021 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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